Regulation Of Upstream Factors Of Mir-9/29a/107 In Neurogenesis
miR-9/29a/107 are key players in neurodegeneration. Hence, we foresee that identifying the upstream regulators of our miRNA biogenesis through QTL mapping in cc mice will reveal the genetic architecture behind this phenomenon. Further, functional studies from Neural Progenitor cells isolated from the hippocampus will identify roles in neurogenesis. This will unveil novel regulatory proteins that target miR-9/29a/107. The in vivo experiments in mice will further unveil the interaction between regulatory protein and miR-9/29a/107 in neurogenesis. The pathways associated with these factors will potentially open new therapeutic interventions to deal with age related cognitive decline and neurodegeneration.